Navegando por Autor "Silva, Henrique Vieira Reis"
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Item Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.(2023) Barbosa, Marília Imaculada Frazão; Correa, Rodrigo de Souza; Macedo, Adriana Pereira Mundim Guedes; Graça, Alex Marchezini; Andrade, Francyelli Mello; Leite, Celisnolia Morais; Lacerda, Elisângela de Paula Silveira; Ellena, Javier Alcides; Silva, Henrique Vieira Reis; Doriguetto, Antônio Carlos; Batista, Alzir AzevedoHerein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.