Navegando por Autor "Sanches, Vitor Lacerda"
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Item Bioaccessibility of some minerals in infant formulas.(2022) Moraes, Maria Rosa de; Silva, Emanueli do Nascimento da; Sanches, Vitor Lacerda; Cadore, Solange; Godoy, Helena TeixeiraTo guarantee the adequate intake of nutrients a variety of food supplementation (including infant formu- las) has been used to ensure the nutrition of infants. Con- sidering that the total concentration of nutrients is not enough to determine whether the food provides all the nutritional needs, the objective of this study was to eval- uate the total concentration and bioaccessibility of some elements in thirty commercial infant formulas consumed in Brazil. A standardized in vitro gastrointestinal digestion method was used to obtain the soluble fraction of each mineral, which was analyzed by ICP OES after microwave oxidative digestion to obtain the bioaccessibility values. The total concentration and the bioaccessibility of the elements varied considerably according to the sample type (traditional infant formulas, formulas for infants with gastrointestinal problems, formulas for premature and soy- based). The bioaccessibility values are 3–43% (Ca), 53–97% (Cu), 35–100% (Fe), 70–114% (K), 47–90% (Mg), 52–95% (P), 31–92% (Zn). In general, the total concentration values for the elements were higher than that declared by the manufacturers, also than the current leg- islation as well, regarding the DRI. Although these results, it is important to emphasize that the consumption of infant formulas can provide an adequate intake of minerals for the infants.Item Formulations with microencapsulated Fe–peptides improve in vitro bioaccessibility and bioavailability.(2022) Gaigher, Bruna; Silva, Emanueli do Nascimento da; Sanches, Vitor Lacerda; Milani, Raquel Fernanda; Galland, Fabiana; Cadore, Solange; Grancieri, Mariana; Pacheco, Maria Teresa BertoldoThe bioaccessibility and the bioavailability of iron complexed to peptides (active) in microparticles forms con- tained in dry beverages formulations were evaluated. The peptide-iron complexes microparticles were obtained by spray drying and added in three dry formulations (tangerine, strawberry, and chocolate flavors). The peptides isolated by iron ion affinity (IMAC-Fe III) had their biological activity predicted by BIOPEP® database and were evaluated by molecular coupling. The bioaccessibility was evaluated by solubility and dialysability and the bioavalability was assessed by Caco-2 cellular model. The proportion 10:1 of peptide-iron complexes presented higher rates of bioaccessibility (49%) and bioavailability (56%). The microparticle with peptide-iron complex showed greater solubility after digestion (39.1%), bioaccessibility (19.8%), and bioavailability (34.8%) than the ferrous sulfate salt (control) for the three assays (10.2%; 12.9%; 9.7%, respectively). Tangerine and strawberry formulations contributed to the iron absorption according to the results of bioaccessibility (36.2%, 30.0% respectively) and bioavailability (80.5%, 84.1%, respectively). The results showed that iron peptide complexa- tion and microencapsulation process improve the bioaccessibility and bioavailability when incorporated into formulations.