Navegando por Autor "Ricardo, Kelly Fabiane Santos"
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Item Associations of flavonoids and natural dyes in the control of lipidic metabolism.(1999) Ricardo, Kelly Fabiane Santos; Oliveira, Tânia Toledo de; Nagem, Tanus Jorge; Pinto, Aloísio da Silva; Stringheta, Paulo CésarThe present work evaluates the effects of rutin and naringenin, isolated and in association with anthocyanin and monascus, on lipidic metabolism of rats. These compounds were dissolved in propylene glycol and administered by intraperitoneal route in two doses of 5mg/kg of body weight. The first dose was administered together witli the Triton, compouiid responsible for induction of hyperlipidaemia, and the second, twenty hours later. After fourty three hours of the first dose aiid Triton administration, the blood was retreat and cliolesterol, HDL-cholesterol, and triacylglycerols were dosed. Results evidence the largest percentual reduction of cholesterol for naringenin + monascus, naringenin + anthocyanin, rutin + monascus and rutin + anthocyanin . On the other hand, for HDL-cholesterol, the best results were obtained with naringenin alone. Finally, the best reduction of triacylglycerols levels was showed for naringenin, naringenin + monascus and rutin + anthocyanin associations.Item Effect of flavonoids morin : quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton.(2001) Ricardo, Kelly Fabiane Santos; Oliveira, Tânia Toledo de; Nagem, Tanus Jorge; Pinto, Aloísio da Silva; Oliveira, Maria Goreti de Almeida; Soares, José FranciscoAtherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morinnicotinic acid combination showed the best triacylglycerols results. Results showed that flavonoids could be beneficious in the treatment of coronary diseases.Item Hypolipidemic effect of flavonoids and cholestyramine in rats.(2007) Oliveira, Tânia Toledo de; Ricardo, Kelly Fabiane Santos; Almeida, Márcia Rogéria de; Costa, Marcelo Rocha da; Nagem, Tanus JorgeEfectos Hipolipidémicos de Flavonoides y Colestiramina en Ratas” . Este trabajo evalúa la acción de quercetina, rutina, morina y naringenina aisladamente y en asociación con colestiramina en el suero sanguíneo de ratas. Estos compuestos fueron mezclados a la dieta (Marca Purina) conteniendo 1% de colesterol y 0,1% de ácido cólico y las sustancias fueron administradas en la dosis de 30 mg para los flavonoides y 10 mg para la colestiramina. Después de treinta días se determinó el contenido de colesterol, colesterol-HDL y triacilgliceroles en sangre. Los resultados evidencian que colestiramina en asociación con quercetina presentaran la mayor reducción de colesterol. Por otro lado, para colesterol-HDL los niveles fueron aumentados en la asociación de colestiramina y naringenina, presentando un efecto sinérgico, mientras los resultados para triacilgliceroles indicaron una reducción en todos los tratamientos, siendo la asociación de colestiramina con flavonoides la que ha mostrado los mejores efectos.