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Item COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020 : study protocol and initial results.(2023) Meireles, Adriana Lúcia; Lourenção, Luciano Garcia; Menezes Junior, Luiz Antonio Alves de; Coletro, Hillary Nascimento; Justiniano, Irene Carolina Sousa; Moura, Samara Silva de; Diniz, Amanda Popolino; Sabião, Thaís da Silva; Rocha, Ana Maria Sampaio; Batista, Aline Priscila; Lage, Nara Nunes; Simões, Bárbara dos Santos; Santos, Carolina Ali; Mendonça, Raquel de Deus; Andrade, Amanda Cristina de Souza; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Carraro, Júlia Cristina Cardoso; Menezes, Mariana Carvalho de; Nascimento, Renata Cristina Rezende Macedo do; Roever, Leonardo; Caiaffa, Waleska Teixeira; Coelho, George Luiz Lins MachadoObjective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to- face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.