Navegando por Autor "Mansego, Maria Luisa"

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    Higher fruit intake is related to TNF-α hypomethylation and better glucose tolerance in healthy subjects.
    (2016) Carraro, Júlia Cristina Cardoso; Hermsdorff, Helen Hermana Miranda; Mansego, Maria Luisa; Zulet, Maria Angeles; Milagro, Fermín Ignacio; Bressan, Josefina; Martínez, J. Alfredo
    Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this crosssectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = –0.460, p = 0.003) and TNF-α total methylation (r = –0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = –0.324, p = 0.041) and TNF-α total methylation (r = –0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = –0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.
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    LINE-1 and inflammatory gene methylation levels are early biomarkers of metabolic changes : association with adiposity.
    (2016) Carraro, Júlia Cristina Cardoso; Mansego, Maria Luisa; Milagro, Fermín Ignacio; Chaves, Larissa Oliveira; Vidigal, Fernanda de Carvalho; Bressan, Josefina; Martinez, Alfredo
    We analyzed whether global and inflammatory genes methylation can be early predictors of metabolic changes and their associations with the diet, in a cross-sectional study (n¼40). Higher global methylation was associated to adiposity, insulin resistance, and lower quality of the diet. Methylation of IL-6, SERPINE1 and CRP genes was related to adiposity traits and macronutrients intake. SERPINE1 hypermethylation was also related to some metabolic alterations. CRP methylation was a better predictor of insulin resistance than CRP plasma concentrations. Global and inflammatory gene promoter hypermethylation can be good early biomarkers of adiposity and metabolic changes and are associated to the quality of the diet.