Navegando por Autor "Leite, Clarice Queico Fujimura"

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    Anti-mycobacterium tuberculosis and cytotoxicity activities of Ruthenium(II)/ bipyridine/diphosphine/pyrimidine-2-thiolate complexes : the role of the non- coordinated N-atom.
    (2016) Benedicto, Augusto Vieira Lima; Correa, Rodrigo de Souza; Graminha, Angelica Ellen; Kuznetsov, Aleksey Evgenyevich; Ellena, Javier Alcides; Pavan, Fernando Rogério; Leite, Clarice Queico Fujimura; Batista, Alzir Azevedo
    The [Ru(Spym)(bipy)(P–P)]PF6, [Spym = pyrimidine-2-thiolate anion; P–P = 1,2-bis(diphenylphosphino)ethane, 1,3-bis(diphenylphosphino)propane and 1,1’-bis(diphenylphosphino)ferrocene] complexes were synthesized and characterized by spectroscopic, electrochemical and elemental analysis, and by X-ray crystallography. The minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis and the complex concentration causing 50% tumor cell growth inhibition (IC50) against breast cancer cells, MDA-MB-231, were determined. All three compounds gave promising values in both tests. It is interesting to mention that all three complexes display MICs against Mycobacterium tuberculosis showing higher activity than cycloserine, a second line drug used in the treatment of the illness. The complexes interact weakly with the DNA.
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    Ruthenium(II) complexes with hydroxypyridinecarboxylates : screening potential metallodrugs against Mycobacterium tuberculosis.
    (2015) Barbosa, Marília Imaculada Frazão; Correa, Rodrigo de Souza; Pozzi, Lucas Vinícius dos Santos; Pavan, Fernando Rogério; Leite, Clarice Queico Fujimura; Ellena, Javier Alcides; Machado, Sérgio de Paula; Poelhsitz, Gustavo Von; Batista, Alzir Azevedo
    Three promising antimycobacterium tuberculosis ruthenium(II) complexes with the deprotonated ligands 2-hydroxynicotinic acid (2-OHnicH), 6-hydroxynicotinic acid (6-OHnicH) and 3-hydroxypicolinic acid (3-OHpicH) were synthesized and characterized. Structural analysis revealed three different coordination modes depending of the hydroxypyridinecarboxylate ligand. In the complex [Ru(2- OHnic)(dppb)(bipy)]PF6 (1), the 2-OHnic anion is coordinated by the O,O-chelating mode (via carboxylate group and phenolate oxygen), in the [Ru(6-OHnic)(dppb)(bipy)]PF6 (2) a O–O chelation by the carboxylate group is observed for the 6-OHnic ligand and for the complex [Ru(3-OHpic)(dppb)(bipy)]PF6 (3) a N,O-chelating mode (via carboxylate) occurs to the 3-OHpic anion. The compounds were evaluated for activity against Mycobacterium tuberculosis H37Rv ATCC 27294 using Resazurin Microtitre Assay (REMA) plate method and cytotoxicity in VERO CCL-81 cell line. All the synthesized compounds exhibited good antimycobacterial activity and a completely lack of cytotoxicity activity, indicating a good selectivity index.