Navegando por Autor "Gomes, Luis Henrique Lobo Silame"

Filtrar resultados informando as primeiras letras
Agora exibindo 1 - 1 de 1
  • Imagem de Miniatura
    Item
    Swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension.
    (2017) Locatelli, Jamille; Paiva, Nívia Carolina Nogueira de; Carvalho, Sara Helena Resende; Lavorato, Victor Neiva; Gomes, Luis Henrique Lobo Silame; Castro, Quênia Janaína Tomaz de; Guimarães, Andrea Grabe; Carneiro, Cláudia Martins; Natali, Antônio José; Isoldi, Mauro César
    Aim: Investigate to what extent low-intensity swim training for six weeks counterbalances the adverse remodeling due to the advance of pathological hypertrophy in the left ventricle (LV) structural and mechanical properties in the early compensated phase of hypertension in male SHR. Main methods: Four-month-old male SHR and Wistar rats were randomly divided into Sed (sedentary) and Ex (exercised) groups. The exercised rats were submitted to a swimming protocol (1 h/day, 5 times/week, no additional load) for six weeks. LV tissue and isolated myocytes were used to assess structural and mechanical properties. Myocytes were stimulted at frequencies (F) of 1 and 3 Hz at 37 °C. Key findings: Exercised SHR showed improvement in cardiovascular parameters compared to sedentary SHR (mean arterial pressure: 13.22%; resting HR: 14.28.%). About structural and mechanical properties, swim training induced a decrease in LV myocyte thickness (10.85%), number of inflammatory cells (21.24%); collagen type III (74.23%) and type I (85.6%) fiber areas; amplitude of single myocyte shortening (47% to F1 and 28.46% to F3), timecourses of shortening (16.5% to F1 and 7.55% to F3) and relaxation (15.31% to F3) compared to sedentary SHR. Significance: Six weeks of swim training attenuates the adverse remodeling of LV structural and mechanical properties in the early compensated phase of hypertension in male SHR.