Navegando por Autor "Freire, Vitória"

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    Ru(II)–thyminate complexes : new metallodrug candidates against tumor cells.
    (2018) Correa, Rodrigo de Souza; Freire, Vitória; Barbosa, Marília Imaculada Frazão; Bezerra, Daniel Pereira; Bomfim, Larissa Mendes; Moreira, Diogo Rodrigo de Magalhães; Soares, Milena Botelho Pereira; Ellena, Javier Alcides; Batista, Alzir Azevedo
    Herein, we used thymine (HThy) as a ligand to form two new ruthenium(II) complexes with formula [Ru(PPh3)2(Thy)(bipy)]PF6 (1) and [Ru(Thy)(bipy)(dppb)]PF6 (2). The complexes were characterized by spectroscopic, spectrometric and X-ray crystallography analyses. Complexes 1 and 2 can interact with ctDNA presenting binding constants, Kb, of 0.4 and 1.2 × 103 M−1, respectively. Their cytotoxic activities towards tumor cell lines (B16-F10, HepG2, K562 and HL-60) and non-tumor cells (PBMCs) were evaluated using the Alamar blue assay. Complex 1 exhibits high cytotoxicity against tumor cells, showing IC50 values of 0.01 and 1.81 μM against the HL-60 and HepG2 cell lines, respectively. Therefore, compound 1 can be considered as a promising antitumor metallodrug.