Navegando por Autor "Donoghue, Mark T. A."
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Item Computational identification and evolutionary relationships of the MicroRNA gene cluster miR-71/2 in protostomes.(2013) Gomes, Matheus de Souza; Donoghue, Mark T. A.; Muniyappa, Mohan Kumar; Pereira, Roberta Verciano; Cota, Renata Guerra de Sá; Spillane, CharlesMicroRNAs (miRNAs) are small noncoding RNA molecules which are processed into *20–24 nt molecules that can regulate the gene expression posttranscriptionally. MiRNA gene clusters have been identified in a range of species, where in miRNAs are often processed from polycistronic transcripts. In this study, a computational approach is used to investigate the extent of evolutionary conservation of the miR-71/2 cluster in animals, and to identify novel miRNAs in the miRNA cluster miR-71/2. The miR-71/2 cluster, consisting of copies of the miR-71 and miR-2 (including miR-13) families, was found to be Protostome-specific. Although, this cluster is highly conserved across the Protostomia, the miR-2 family is completely absent from the Deuterostomia species, while miR-71 is absent from the Vertebrata and Urochordata. The evolutionary conservation and clustering propensity of the miR-71/2 family across the Protostomes could indicate the common functional roles across the member species of the Protostomia.