Navegando por Autor "Brancaglion, Gustavo Andrade"

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    No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation.
    (2020) Costa, Karla Cristinne Mancini; Brancaglion, Gustavo Andrade; Almeida, Carolina Aparecida de Faria; Amorim, Gabriel Estevam Santos de; Veloso, Luciana Lopes; Lião, Lucas da Silva; Souza, Gabriel Augusto Pires de; Pereira, Bruna Pinheiro; Angelo, Marilene Lopes; Ruginsk, Silvia Graciela; Brandão, Wesley Nogueira; Marcourakis, Tania; Ceron, Carla Speroni; Coelho, Luiz Felipe Leomil; Torres, Larissa Helena
    Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time- related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.