Navegando por Autor "Barbosa, Keila Furbino"

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COVID-Inconfidentes - SARS-CoV-2 seroprevalence in two Brazilian urban areas in the fourth quarter 2020 : study protocol and initial results.
(2023) Meireles, Adriana Lúcia; Lourenção, Luciano Garcia; Menezes Junior, Luiz Antonio Alves de; Coletro, Hillary Nascimento; Justiniano, Irene Carolina Sousa; Moura, Samara Silva de; Diniz, Amanda Popolino; Sabião, Thaís da Silva; Rocha, Ana Maria Sampaio; Batista, Aline Priscila; Lage, Nara Nunes; Simões, Bárbara dos Santos; Santos, Carolina Ali; Mendonça, Raquel de Deus; Andrade, Amanda Cristina de Souza; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Carraro, Júlia Cristina Cardoso; Menezes, Mariana Carvalho de; Nascimento, Renata Cristina Rezende Macedo do; Roever, Leonardo; Caiaffa, Waleska Teixeira; Coelho, George Luiz Lins Machado
Objective: To describe study protocol and initial results of research project COVID-Inconfidentes. Method: This paper described the methodological procedures adopted and the prevalence of the SARS-CoV-2 infection in the population. A household survey was conducted between October and December 2020, in two historic cities of Brazil's mining region. Anti-SARS-CoV-2 antibody was detected using the Wondfo® rapid test. The face-to- face interview consisted of administration of a questionnaire containing registration data, sociodemographic and economic variables, living habits, general health condition, mental health, sleep habits, and eating and nutrition. Results: We evaluated 1,762 residents, of which 764 (43.4 %) were in Mariana and 998 (56.6 %) in Ouro Preto. For both cities, 51.9 % of the interviewees were female, with a predominance of the age range 35 to 59 years old (47.2 %). The prevalence of the SARS-CoV-2 infection was 5.5 % in both cities, 6.2 % in Ouro Preto, and 4.7 % in Mariana (p-value > 0.05). Conclusion: The study was effective to estimate the seroprevalence of infection by the virus and its findings will enable further analyses of the health conditions of the population related to social isolation and the risk of infection with SARS-CoV-2.
Factors associated with non-use of condoms and prevalence of HIV, viral hepatitis B and C and syphilis : a cross-sectional study in rural communities in Ouro Preto, Minas Gerais, Brazil, 2014-2016.
(2019) Barbosa, Keila Furbino; Batista, Aline Priscila; Nacife, Maria Beatriz Pena e Silva Leite; Vianna, Valeska Natiely; Oliveira, Wandeir Wagner de; Machado, Elaine Leandro; Marinho, Carolina Coimbra; Coelho, George Luiz Lins Machado
Objective: to investigate socio-demographic factors associated with non-use of condoms, and to describe the prevalence of sexually transmitted infections (STI) in rural communities of Ouro Preto, Minas Gerais, Brazil, 2014 to 2016. Methods: data were gathered from individual interviews and rapid tests were performed; associations were tested using Poisson regression, with a 95% confidence interval (95%CI). Results: we detected 3.8 cases/10,000 inhabitants for hepatitis B and syphilis, and 1.3 cases/10,000 inhabitants for hepatitis C; no HIV cases were detected; in the multivariate analysis we found higher prevalence rates of condom non-use among the group of individuals who were married, had common law partners or were widowed (PR=1.20 – 95%CI 1.06;1.36). Conclusion: individuals in a stable relationship formed the group with the highest prevalence rate of condom non-use; new syphilis and viral hepatitis cases were detected using rapid tests during the survey.
Fatores associados ao hábito de não usar preservativo e prevalência de HIV, hepatites virais B e C e sífilis : estudo transversal em comunidades rurais de Ouro Preto, Minas Gerais, 2015.
(2019) Barbosa, Keila Furbino; Coelho, George Luiz Lins Machado; Marinho, Carolina Coimbra; Gonçalves, Luana Giatti; Meireles, Adriana Lúcia; Marinho, Carolina Coimbra; Coelho, George Luiz Lins Machado
Introdução: As infecções sexualmente transmissíveis representam uma das principais causas de morbi-mortalidade no Brasil. Aspectos locais das epidemias são ainda pouco explorados. Objetivo: este estudo de prevalência teve como objetivo descrever o perfil sociodemográfico de três populações rurais com população predominantemente afrodescendente no município de Ouro Preto, Minas Gerais, duas tradicionais e uma flutuante, quanto ao hábito de usar preservativo nas relações sexuais, a fim de identificar a presença de comportamento sexual de risco, e estimar as prevalências de infecção por HIV, hepatites B, hepatite C e sífilis nessas populações, entre 2014 a 2016. Materiais e métodos: Foram coletados dados de entrevista individual e realizados testes rápidos na população adulta ( > 18 anos) dos distritos Lavras Novas, Santo Antônio do Salto e Antônio Pereira. O inquérito de prevalência com um tamanho amostral 819 indivíduos utilizando questionários semiestruturados e testes sorológicos imunocromatográficos para o rastreamento de HBV (hepatitis B virus) e HCV (hepatitis C virus) e sífilis e diagnóstico de HIV (human immunodeficiency vírus). Os testes positivos para HBV, HCV e sífilis foram confirmados pelo método laboratorial HBSAg (antígeno Austrália), anti HCV (anticorpo contra HCV), (VDRL - Venereal Disease Research Laboratory e FTAABs - Fluorescent Treponemal Antibody-Absorption), respectivamente. As associações foram testadas pelo modelo de regressão de Poisson, com intervalo de confiança de 95% (IC95%). O projeto foi aprovado pelo Comitê de Ética em Pesquisa com seres humanos da Universidade Federal de Ouro Preto (CAAE 07952412.0.0000.5150). Resultados: no distrito de Lavras Novas, 320 pessoas entre 18 e 90 anos participaram da pesquisa. A prevalência de hepatite C após testes confirmatórios foi de 0,9% (n=3/320). Em Santo Antônio do Salto, 290 pessoas entre 18 e 96 anos participaram. A prevalência de sífilis após testes confirmatórios foi 0,7% (n=2/290). Em Antônio Pereira, 147 pessoas entre 19 a 80 anos participaram. As prevalências de sífilis e hepatite B, após testes confirmatórios, foram 0,7% (n=1/147). Não houve nenhum caso confirmado de HIV nos distritos envolvidos. Na análise multivariada, foram encontradas maiores prevalências de não uso de preservativos entre indivíduos casados/em união estável/viúvos (RP=1,20 – IC95% 1,06;1,36). Conclusão: novos casos de sífilis e de hepatites virais foram detectados pelo teste rápido, aplicado no inquérito; o grupo com maior prevalência de não uso de preservativo é o de pessoas com relacionamento fixo.
High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil.
(2020) Batista, Aline Priscila; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Queiroz, Erica Maria de; Marinho, Carolina Coimbra; Cândido, Ana Paula Carlos; Coelho, George Luiz Lins Machado
Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI: 1.23–2.98], insulin resistance (OR=1.82, 95%CI: 1.03–3.22), age (OR=1.64, 95%CI: 1.08–2.49), and sex (OR=1.99, 95%CI: 1.35–2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI: 1.03–2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI: 1.01–2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI: 1.25–3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.
Hypertension is associated with a variant in the RARRES2 gene in populations of Ouro Preto, Minas Gerais, Brazil : a cross-sectional study.
(2021) Batista, Aline Priscila; Barbosa, Keila Furbino; Azevedo, Rafael Júnior de; Vianna, Valeska Natiely; Queiroz, Erica Maria de; Marinho, Carolina Coimbra; Coelho, George Luiz Lins Machado
Background: Arterial hypertension (AH) is implicated in vascular health and contributes significantly to cardiovascular morbidity and mortality. In addition to the contribution of usual risk factors for AH, elucidating the influence of genetic factors is a promising area of investigation. Therefore, we evaluated the association between AH and cardiovascular risk factors (CVRFs) and genetic polymorphisms in communities in Southeast Brazil. Methods: A total of 515 adults aged 18-91 years, who were cross-sectionally assessed between 2015-2016, were included. Demographic, clinical, behavioral, anthropometric characteristics, and laboratory parameters and 12 single nucleotide polymorphisms in seven candidate genes involved in cardiovascular risk (RARRES2, AGT, NOS3, GNB3, APOE, APOB, APOC3, LDLR, and PPARG) were evaluated, with AH as the outcome. Sex, age, and laboratory parameters were considered the main confounding factors. Results: There was a significant association between age >60 years (odds ratio [OR] =6.74), alcohol dependence (OR=3.84), smoking (OR=1.74), overweight (OR=1.74), high plasma triglyceride (TG) levels (OR=1.98) and low high-density lipoprotein (HDL-c) (OR=6.22), diabetes (OR=3.68), and insulin resistance (OR=2.40) and AH. A significant association was observed between rs4721 in RARRES2 and AH. The T allele in homozygosis was a potent chance modifier for AH. The highest chance gradients for AH were characterized by the presence of the TT genotype and DMT2 (OR=9.70), high TG (OR=6.26), low HDL-c (OR=8.20), and age more than 60 years (OR=9.96). Conclusion: The interaction of the T allele of the rs4721 polymorphism in RARRES2 with CVRFs may predispose carriers to a higher cardiovascular risk.
Prevalence of schistosomiasis mansoni in indigenous Maxakali villages, Minas Gerais, Brazil.
(2018) Nacife, Maria Beatriz Pena e Silva Leite; Siqueira, Liliane Maria Vidal; Martins, Rafael; Vianna, Valeska Natiely; Barbosa, Keila Furbino; Masioli, Cássio Zumerle; Silva, Jaime Costa da; Coelho, George Luiz Lins Machado
Intestinal parasitic infections are a common health problem among Amerindian populations and schistosomiasis represents one of the most prevalent diseases in Maxakali people. The Kato-Katz is the diagnostic method recommended by WHO for epidemiological studies; however, one of the technique’s limitations is the failure to detect parasites in individuals with low parasite load. The aim of this study was to establish the prevalence of Schistosoma mansoni in indigenous Maxakali villages, evaluating the TF-Test® performance for diagnosis compared to the Kato-Katz technique. Stool samples from 545 individuals were processed by the TF-Test® (1 sample) and Kato-Katz (1 slide). The positivity rate for S. mansoni by Kato-Katz was 45.7%. The rate by the TF-Test® was 33.2%, and 51.9% by the combined parasitological techniques. The amplitude of parasite load was 24 to 4,056 eggs per gram of feces (epg), with a geometric mean of 139 epg. The co-positivity, co-negativity, and accuracy values by TF-Test® in relation to Kato-Katz were 59.0%, 88.5%, and 75.0%, respectively. The agreement between these techniques was moderate (k=0.486) as determined by the kappa index. Thus, the results of this study demonstrated that the performance of Kato-Katz was superior (p <0.05) to that of TF-Test® in the detection of S. mansoni. The combination of TF-Test® and Kato-Katz resulted in an increased positivity rate of S. mansoni, demonstrating the high risk of infection to which indigenous populations are exposed and the importance of the implementation of control strategies in Maxakali villages.